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CHEK2 anticorps (AA 514-518)
CHEK2
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5689596
Détail du produit anti-CHEK2 anticorps
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Antigène
Voir toutes CHEK2 Anticorps
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Épitope
Tous les épitopes à travers CHEK2 Anticorps.
AA 514-518
Reactivité
Toutes les réactivités sur CHEK2 Anticorps
Humain
Hôte
Toutes les hôtes sur CHEK2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur CHEK2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers CHEK2 Anticorps
Cet anticorp CHEK2 est non-conjugé
Application
Tous les applications à travers CHEK2 Anticorps.
Western Blotting (WB)
Specificité
This antibody detects endogenous levels of total Chk2 protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogène
Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.
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Information d'application
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Indications d'application
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store antibody at -20°C for up to one year.
Détails sur CHEK2
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Antigène
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Autre désignation
Chk2 (CHEK2 Produits )
Synonymes
anticorps CDS1, anticorps CHK2, anticorps HuCds1, anticorps LFS2, anticorps PP1425, anticorps RAD53, anticorps hCds1, anticorps fa66f08, anticorps wu:fa66f08, anticorps zgc:55865, anticorps Cds1, anticorps HUCDS1, anticorps Rad53, anticorps Chk2, anticorps cds1, anticorps chek2, anticorps chk2, anticorps hucds1, anticorps lfs2, anticorps pp1425, anticorps rad53, anticorps checkpoint kinase 2, anticorps serine/threonine-protein kinase chk2, anticorps checkpoint kinase 2 L homeolog, anticorps CHEK2, anticorps chek2, anticorps Chek2, anticorps MCYG_07308, anticorps chek2.L
Sujet
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
Poids moléculaire
62 kDa
ID gène
11200
NCBI Accession
NP_001005735
UniProt
O96017
Pathways
Signalisation p53 , Apoptose , Cycle Cellulaire
Vus récemment
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