BMPR2 anticorps (AA 455-512)

N° du produit ABIN5693167

Détail du produit anti-BMPR2 anticorps

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Épitope: AA 455-512

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMPR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Marque: Picoband™

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for BMPR2 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogène: E. coli-derived human BMPR2 recombinant protein (Position: R455-K512).

Information d'application

Indications d'application:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-BMPR2 (ABIN5693167)

Hanusek, Rybicka, Popławski, Adamiok-Ostrowska, Głuchowska, Piekiełko-Witkowska, Bogusławska: "TGF‑β1 affects the renal cancer miRNome and regulates tumor cells proliferation." dans: International journal of molecular medicine, Vol. 49, Issue 4, (2022) (PubMed).

Liu, Zhong, Yuan, Chen, Zhou, An, Guo, Fan, Li, Sun, Li, Shi, Weng: "MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway." dans: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3379-3393, (2018) (PubMed).

Détails sur BMPR2

Antigène: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Autre désignation: BMPR2 (BMPR2 Produits)

Synonymes: anticorps BMPR-II, anticorps BMPR3, anticorps BMR2, anticorps BRK-3, anticorps PPH1, anticorps T-ALK, anticorps 2610024H22Rik, anticorps AL117858, anticorps AW546137, anticorps BB189135, anticorps BMP-2, anticorps BMPR-2, anticorps BMPRII, anticorps Gm20272, anticorps Bmpr-II, anticorps bmprii, anticorps bone morphogenetic protein receptor type 2, anticorps bone morphogenetic protein receptor, type II b (serine/threonine kinase), anticorps bone morphogenetic protein receptor, type II (serine/threonine kinase), anticorps BMPR2, anticorps bmpr2b, anticorps Bmpr2

Sujet:

Synonyms: Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1

Tissue Specificity: Highly expressed in heart and liver.

Background: Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

UniProt: Q13873

Pathways: Growth Factor Binding