RBPJ anticorps
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- Antigène Voir toutes RBPJ Anticorps
- RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp RBPJ est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Immunogène
- recombination signal binding protein for immunoglobulin kappa J region
- Isotype
- IgG1
- Top Product
- Discover our top product RBPJ Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))
- Autre désignation
- RBPJ (RBPJ Produits)
- Synonymes
- anticorps AOS3, anticorps CBF1, anticorps IGKJRB, anticorps IGKJRB1, anticorps KBF2, anticorps RBP-J, anticorps RBPJK, anticorps RBPSUH, anticorps SUH, anticorps csl, anticorps AI843960, anticorps Igkjrb, anticorps Igkrsbp, anticorps RBP-J kappa, anticorps RBPjk, anticorps Rbpsuh, anticorps Su(H), anticorps XSu(H), anticorps xsu(h)1, anticorps Su(H)1, anticorps Su(h)A, anticorps ik:tdsubc_1e8, anticorps rbpj, anticorps rbpsuh, anticorps xx:tdsubc_1e8, anticorps Su(H)2, anticorps su(h)B, anticorps recombination signal binding protein for immunoglobulin kappa J region, anticorps recombination signal binding protein for immunoglobulin kappa J region S homeolog, anticorps recombination signal binding protein for immunoglobulin kappa J region a, anticorps recombination signal binding protein for immunoglobulin kappa J region b, anticorps RBPJ, anticorps Rbpj, anticorps rbpj.S, anticorps rbpja, anticorps rbpjb
- Sujet
- Synonyms:IGKJRB, IGKJRB1, RBPJK, RBPSUH Background:Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins(Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions(4 % oxygen)(PubMed:23303788).
- ID gène
- 3516
- UniProt
- Q06330
- Pathways
- Signalisation Notch, Stem Cell Maintenance, Smooth Muscle Cell Migration
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