PIK3CB anticorps (Catalytic Subunit beta, N-Term)

N° du produit ABIN5706834

Détail du produit anti-PIK3CB anticorps

Antigène: PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))

Épitope: Catalytic Subunit beta, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3CB est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit:

Synonyms: rabbit anti-PIK3CB antibody, rabbit anti-PI3K beta antibody, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase subunit beta, PI3K-ß, PI3Kbeta, PtdIns-3-kinase subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta, PIK3C1

Background: PIK3CB is a catalytic subunit of phosphoinositide-3-kinase beta. PIK3CB catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process. PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Furthermore, PI3KCB down regulation can suppress cell growth in malignant gliomas. Anti-PIK3C beta Antibody is suitable for researcher in Cancer, Immunology and Nuclear Signaling research.

Gene Name: PIK3CB

Purification: Anti-PIK3C beta was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific for human PIK3C beta protein.  A BLAST analysis was used to suggest cross-reactivity with PI3K-beta based on a 100% homology from human sources with the immunizing sequence.  Expect partial cross reactivity to PIK3C beta from mouse and rat (93% homology) sources.  Cross-reactivity with PIK3C beta from other sources has not been determined.

Immunogène:

Immunogen: This affinity purified PIK3C-ß antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an N-terminal region of human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform.

Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application:

Application Note: Anti-PIK3C beta Antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 122.7 kDa in size corresponding to PI3K beta by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1.0 μg/mL

ELISA Dilution: 1:50,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.09 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride,  pH 7.2

Stabilizer: None

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 12 months

Détails sur PIK3CB

Antigène: PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))

Autre désignation: PIK3CB (PIK3CB Produits)

Synonymes: anticorps P110BETA, anticorps PI3K, anticorps PI3KBETA, anticorps PIK3C1, anticorps fb92a07, anticorps wu:fb92a07, anticorps 1110001J02Rik, anticorps AI447572, anticorps p110beta, anticorps PI3Kbeta, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta, anticorps PIK3CB, anticorps pik3cb, anticorps Pik3cb

ID gène: 5291

NCBI Accession: NP_006210

UniProt: P42338