CFTR / Cystic Fibrosis Transmembrane Regulator anticorps

N° du produit ABIN5707645

Détail du produit

Antigène: CFTR / Cystic Fibrosis Transmembrane Regulator

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: A recombinant human partial protein was used as the immunogen for this recombinant CFTR antibody.

Clone: RCFTR-1342

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant CFTR antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: CFTR / Cystic Fibrosis Transmembrane Regulator

Sujet: CFTR functions as an ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl−,) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.[5] This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation. CFTR is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, and the reproductive tract. [Wiki]

ID gène: 1080