MALT1 anticorps (AA 701-808)

N° du produit ABIN6164434

Détail du produit anti-MALT1 anticorps

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Épitope: AA 701-808

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MALT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Fonction: Mouse Monoclonal anti-MALT-1 (MT1/410), Purified, BSA-free

Attributs du produit: Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Purification: Purified

Immunogène: Human MALT1 recombinant fragment (aa701-808)

Clone: MT1-410

Isotype: IgG1 kappa

Information d'application

Indications d'application: Western blotting 0.5-1 μg/mL, Immunohistology formalin-fixed 0.5-1 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

Jurkat, Daudi or HeLa cells. Tonsil or lymphoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (no BSA, no azide)

Agent conservateur: Azide free

Détails sur MALT1

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Autre désignation: MALT-1 (MALT1 Produits)

Synonymes: anticorps malt1, anticorps MALT1, anticorps mlt, anticorps mlt1, anticorps MLT, anticorps MLT1, anticorps A630046N12, anticorps D430033E09Rik, anticorps MALT paracaspase 2, anticorps MALT1 paracaspase, anticorps MALT1 paracaspase S homeolog, anticorps paracaspase 3, anticorps malt2, anticorps MALT1, anticorps malt1.S, anticorps Malt1, anticorps PCASP3

Sujet: Caspase-like protein, MALT lymphoma-associated translocation, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase

Poids moléculaire: 93 kDa

ID gène: 10892, 601217

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins