H2AFX anticorps (pSer139)
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- Antigène Voir toutes H2AFX Anticorps
- H2AFX (H2A Histone Family, Member X (H2AFX))
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Épitope
- pSer139
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp H2AFX est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Specificité
- Phospho-Histone H2A.X (Ser139) Antibody detects endogenous levels of Histone H2A.X only when phosphorylated at Ser139, which site historically referenced as Ser140.
- Homologie
- Bovine,Sheep,Dog
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human Histone H2A.X around the phosphorylation site of Ser139.
- Isotype
- IgG
- Top Product
- Discover our top product H2AFX Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- H2AFX (H2A Histone Family, Member X (H2AFX))
- Autre désignation
- H2AFX (H2AFX Produits)
- Synonymes
- anticorps H2A.X, anticorps H2A/X, anticorps H2AX, anticorps AW228881, anticorps H2ax, anticorps Hist5-2ax, anticorps gammaH2ax, anticorps zgc:56329, anticorps h2a.x, anticorps h2a/x, anticorps h2ax, anticorps RGD1566119, anticorps h2a, anticorps h2afx, anticorps H2A histone family member X, anticorps H2A histone family, member X, anticorps H2A histone family member X L homeolog, anticorps histone cluster 1, H2ah, anticorps histone cluster 2, H2ab S homeolog, anticorps histone H2AX, anticorps H2AFX, anticorps H2afx, anticorps h2afx, anticorps h2afx.L, anticorps HIST1H2AH, anticorps hist2h2ab.S, anticorps LOC100522201, anticorps LOC100720536
- Sujet
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Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Gene: H2AFX
- Poids moléculaire
- 15kDa
- ID gène
- 3014
- UniProt
- P16104
- Pathways
- Telomere Maintenance, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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