DDR2 anticorps (Internal Region)

N° du produit ABIN6258108

Détail du produit anti-DDR2 anticorps

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: DDR2 Antibody detects endogenous levels of total DDR2.

Homologie: Pig,Bovine,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DDR2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur DDR2

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Autre désignation: DDR2 (DDR2 Produits)

Synonymes: anticorps MIG20a, anticorps NTRKR3, anticorps TKT, anticorps TYRO10, anticorps AW495251, anticorps Ntrkr3, anticorps tyro10, anticorps DDR2, anticorps Tyro10, anticorps ddr2, anticorps si:ch211-193c2.1, anticorps discoidin domain receptor tyrosine kinase 2, anticorps discoidin domain receptor family, member 2, anticorps discoidin domain receptor family, member 2, like, anticorps DDR2, anticorps Ddr2, anticorps ddr2l

Sujet:

Description: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Gene: DDR2

Poids moléculaire: 97 kDa

ID gène: 4921

UniProt: Q16832

Pathways: Signalisation RTK