WWTR1 anticorps (Internal Region)
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- Antigène Voir toutes WWTR1 Anticorps
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp WWTR1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- TAZ Antibody detects endogenous levels of total TAZ.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human TAZ, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product WWTR1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- Autre désignation
- WWTR1 (WWTR1 Produits)
- Synonymes
- anticorps WWTR1, anticorps TAZ, anticorps 2310058J06Rik, anticorps 2610021I22Rik, anticorps C78399, anticorps Taz, anticorps WW domain containing transcription regulator 1 L homeolog, anticorps WW domain containing transcription regulator 1, anticorps wwtr1.L, anticorps wwtr1, anticorps WWTR1, anticorps Wwtr1
- Sujet
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Description: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Gene: WWTR1
- Poids moléculaire
- 44 kDa
- ID gène
- 25937
- UniProt
- Q9GZV5
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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