Cofilin anticorps (pSer3)

N° du produit ABIN6280545

Détail du produit anti-Cofilin anticorps

Antigène: Cofilin (CFL1) (Cofilin 1 (CFL1))

Épitope: AA 10-90, pSer3

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cofilin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Cofilin is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. Cofilin is localised to the endomembrane system and is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, Th17 cell differentiation and IL27-mediated signalling events. It phosphorylates STAT proteins and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Cofilin is expressed at higher levels in primary colon tumor than normal colon tissue. Mutations in the JAK1 gene may result in mixed lacrimal gland cancer, t-cell prolymphocytic leukemia and chilblain lupus. The antibody STJ90230 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Cofilin protein which only binds about S3 when S3 is phosphorylated.

Specificité: Phospho-Cofilin (S3) Polyclonal Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.

Attributs du produit: Rabbit polyclonal to Phospho-Cofilin (S3).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Cofilin around the phosphorylation site of S3.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000

Commentaires:

Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Cofilin

Antigène: Cofilin (CFL1) (Cofilin 1 (CFL1))

Autre désignation: Cofilin (CFL1 Produits)

Synonymes: anticorps cfl1, anticorps xac1, anticorps xac2, anticorps cfl, anticorps cb86, anticorps sb:cb86, anticorps zgc:56501, anticorps wu:fb18a04, anticorps wu:fk77b03, anticorps 12/8, anticorps ADF, anticorps ADF/cofilin, anticorps Adf, anticorps CG4254, anticorps Cadf, anticorps D-cof, anticorps D61, anticorps Dmel\\CG4254, anticorps T8, anticorps Tsr, anticorps cofilin, anticorps cofilin/ADF, anticorps cofilin/actin depolymerizing factor homolog, anticorps l(2)03101, anticorps l(2)k03101, anticorps l(2)k05633, anticorps l(2)k13409, anticorps ntf, anticorps CFL, anticorps AA959946, anticorps Cof, anticorps CFL1, anticorps cofilin 1 (non-muscle) L homeolog, anticorps cofilin 1 (non-muscle), anticorps cofilin 1 (non-muscle), like, anticorps cofilin 1, anticorps twinstar, anticorps cofilin, anticorps cofilin 1, non-muscle, anticorps Contrafreeloading, anticorps cfl1.L, anticorps cfl1, anticorps cfl1l, anticorps CFL1, anticorps tsr, anticorps COF1, anticorps TSTA_042790, anticorps Cfl1, anticorps CFL

Poids moléculaire: 19 kDa

ID gène: 1072

UniProt: P23458

Pathways: Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events