E2F1 anticorps (pThr433)

N° du produit ABIN6283586

Détail du produit anti-E2F1 anticorps

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Épitope: AA 370-450, pThr433

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F1 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: E2F-1 is a protein encoded by the E2F1 gene which is approximately 46,9 kDa. E2F-1 is localised to the nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, glioma, E2F mediated regulation of DNA replication and activation of BH3-only proteins. It is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. E2F-1 is expressed in the skin, pancreas and nervous system. Mutations in the E2F1 gene may result in retinoblastoma and pharyngoconjunctival fever. STJ90458 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous E2F-1 protein which only binds about T433 when T433 is phosphorylated.

Specificité: Phospho-E2F-1 (T433) Polyclonal Antibody detects endogenous levels of E2F-1 protein only when phosphorylated at T433.

Attributs du produit: Rabbit polyclonal to Phospho-E2F-1 (T433).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human E2F-1 around the phosphorylation site of T433.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
ELISA 1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur E2F1

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Autre désignation: E2F-1 (E2F1 Produits)

Synonymes: anticorps CG6376, anticorps DRTF1/E2F, anticorps DmE2F-1, anticorps Dmel\\CG6376, anticorps Dp, anticorps E(Sev-CycE)3A, anticorps E(var)3-93E, anticorps E(var)3-95E, anticorps E(var)93E, anticorps E2F, anticorps E2F-1, anticorps E2F1, anticorps E2f1, anticorps Evar(3)164, anticorps dE2F, anticorps dE2F1, anticorps dE2f, anticorps dE2f1, anticorps de2f1, anticorps def21, anticorps drosE2F1, anticorps e2f, anticorps e2f1, anticorps l(3)07172, anticorps l(3)j3B1, anticorps l(3)j3C2, anticorps l(3)rM729, anticorps RBAP1, anticorps RBBP3, anticorps RBP3, anticorps mKIAA4009, anticorps xE2F, anticorps ATE2FB, anticorps E2F TRANSCRIPTION FACTOR-1 E2F1, anticorps E2F transcription factor 1, anticorps E2FB, anticorps E2FB TRANSCRIPTION FACTOR, anticorps E2F transcription factor 1, anticorps E2F transcription factor 1 L homeolog, anticorps E2f1, anticorps E2F1, anticorps e2f1.L

Poids moléculaire: 47 kDa

ID gène: 1869

UniProt: Q01094

Pathways: Signalisation p53, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy