AXL anticorps (pTyr691)

N° du produit ABIN6284698

Détail du produit anti-AXL anticorps

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Épitope: AA 630-710, pTyr691

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Axl is a protein encoded by the AXL gene which is approximately 98,3 kDa. Axl is localised to the cell membrane. It is involved in the GPCR pathway, ERK signalling, actin nucleation by ARP-WASP complex and activation of cAMP-dependent PKA. This protein falls under the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6. Axl is expressed in primary colon tumors but weakly expressed in normal colon tissue. Mutations in the AXL gene may result in lymphocytic choriomeningitis, femoral neuropathy and Borna disease. STJ90939 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Axl protein which only binds about Y691 when Y691 is phosphorylated.

Specificité: Phospho-Axl (Y691) Polyclonal Antibody detects endogenous levels of Axl protein only when phosphorylated at Y691.

Attributs du produit: Rabbit polyclonal to Phospho-Axl (Y691).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Axl around the phosphorylation site of Y691.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur AXL

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Autre désignation: Axl (AXL Produits)

Synonymes: anticorps JTK11, anticorps UFO, anticorps AI323647, anticorps Ark, anticorps Tyro7, anticorps Ufo, anticorps AXL receptor tyrosine kinase, anticorps Axl receptor tyrosine kinase, anticorps AXL, anticorps Axl

Poids moléculaire: 110/97 kDa

ID gène: 558

UniProt: P30530

Pathways: Signalisation RTK, Cellular Response to Molecule of Bacterial Origin