VEGFA anticorps (Internal Region)

N° du produit ABIN6287156

Détail du produit anti-VEGFA anticorps

Antigène: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VEGFA est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Fonction: VEGFA is a protein encoded by the VEGFA gene which is approximately 27,1 kDa. VEGFA is freely secreted. It is involved in the response to elevated platelet cytosolic Ca2+, development VEGF signalling, CDK-mediated phosphorylation and removal of Cdc6 and RET signalling. It is a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Isoform VEGF189, VEGF165 and VEGF121 are widely expressed in human tissues. Mutations in the VEGFA gene may result in microvascular complications of diabetes. This gene is also upregulated in many known tumors. STJ96235 was affinity purified. This polyclonal antibody binds to VEGFA.

Specificité: VEGF-A Polyclonal Antibody detects endogenous levels of VEGF-A protein.

Attributs du produit: Rabbit polyclonal to VEGFA.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human VEGF-A.

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100-1:300
ELISA 1:10000

Commentaires:

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur VEGFA

Antigène: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Autre désignation: VEGFA (VEGFA Produits)

Synonymes: anticorps MVCD1, anticorps VEGF, anticorps VPF, anticorps Vegf, anticorps Vegf120, anticorps Vegf164, anticorps Vegf188, anticorps Vpf, anticorps vegf, anticorps vegfa, anticorps wu:fj82c06, anticorps VEGF-A, anticorps VEGF164, anticorps eVEGF120, anticorps eVEGF164, anticorps vegf-a, anticorps vpf, anticorps vefg, anticorps si:dkey-14d8.3, anticorps wu:fd42e02, anticorps vascular endothelial growth factor A, anticorps vascular endothelial growth factor Aa, anticorps vascular endothelial growth factor A L homeolog, anticorps vascular endothelial growth factor Ab, anticorps VEGFA, anticorps Vegfa, anticorps vegfaa, anticorps vegfa.L, anticorps vegfa, anticorps vegfab

Poids moléculaire: 27 kDa

ID gène: 7422

UniProt: P15692

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling