ErbB2/Her2 anticorps (N-Term)

N° du produit ABIN6287432

Détail du produit anti-ErbB2/Her2 anticorps

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: HER2 is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. HER2 isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the cytoplasm and nucleus. It is involved in RET signalling, the GPCR pathway and signalling by ERBB2. It is a protein tyrosine kinase that is part of several cell surface receptor complexes that need a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex and also regulates outgrowth and stabilization of peripheral microtubules. HER2 is expressed in the cells of the nervous system, liver, intestine, lymph nodes and lung. Mutations in the ERBB2 gene may result in Glioma. STJ96947 was developed from clone 11H9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous ErbB-2/HER-2 proteins.

Specificité: The antibody detects endogenous ErbB-2/HER-2 proteins.

Attributs du produit: Mouse monoclonal to HER2.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogène: Synthetic Peptide

Clone: 11H9

Isotype: IgG1

Information d'application

Indications d'application: WB 1:2000-4000
IHC 1:200

Commentaires:

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: HER2 (ErbB2/Her2 Produits)

Synonymes: anticorps CD340, anticorps HER-2, anticorps HER-2/neu, anticorps HER2, anticorps MLN 19, anticorps NEU, anticorps NGL, anticorps TKR1, anticorps Erbb-2, anticorps Neu, anticorps c-erbB2, anticorps c-neu, anticorps mKIAA3023, anticorps wu:fv70f10, anticorps zgc:63601, anticorps erb2, anticorps erb-b2 receptor tyrosine kinase 2, anticorps ERBB2, anticorps Erbb2, anticorps erbb2

ID gène: 2064

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development