TRAIL anticorps

N° du produit ABIN640733

Détail du produit anti-TRAIL anticorps

Antigène: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit Anti-Human CD253

Specificité: DS-PB-02541 is specific for human CD253, otherwise known as TRAIL or Apo2L, a 281 amino acid type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily, which induces apoptosis in tumor and transformed cells, but not normal cells. Activation of apoptosis by CD253 occurs through binding to the death-signaling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signaling complex (DISC) and the triggering of a proteolytic caspase cascade. There are however decoy receptors known as DcR1 (TRAILR3) and DcR2 (TRAILR4) which competitively bind to CD253 and are unable to initiate apoptosis. CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumor and anti-viral cytotoxicity.

Attributs du produit: Adhesion Molecule/Cell Surface

Purification: Purified

Immunogène: Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: ELISA (dilution: 0.1, 0.2 μg/mL), Immunohistology - Paraffin, Western Blotting

Restrictions: For Research Use only

Stockage

Reconstitution: Reconstitute with 0.1 mL distilled water. For long term storage the addition of 0.09 % sodium azide is recommended.

Concentration: IgG concentration 1.0 mg/ml after reconstitution

Buffer: Phosphate buffered saline pH7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur TRAIL

Antigène: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Autre désignation: CD253 (TNFSF10 Produits)

Synonymes: anticorps APO2L, anticorps Apo-2L, anticorps CD253, anticorps TL2, anticorps TRAIL, anticorps A330042I21Rik, anticorps AI448571, anticorps APO-2L, anticorps Ly81, anticorps Trail, anticorps tl2, anticorps apo2l, anticorps cd253, anticorps trail, anticorps apo-2l, anticorps trail1, anticorps xtrail1, anticorps tnfsf10l2, anticorps zgc:92320, anticorps TNLG6A, anticorps TNF superfamily member 10, anticorps tumor necrosis factor (ligand) superfamily, member 10, anticorps tumor necrosis factor superfamily member 10, anticorps TNF superfamily member 10 S homeolog, anticorps TNFSF10, anticorps Tnfsf10, anticorps tnfsf10.S, anticorps tnfsf10

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity