CASP5 anticorps

N° du produit ABIN643987

Détail du produit anti-CASP5 anticorps

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASP5 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit Anti-Human CASP5

Specificité: DS-PB-00380 recognizes an epitope located within the internal region of human Caspase5, a 47kDa cysteine protease, otherwise known as ICH3. Caspase5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes. Caspase5 is a member of a growing number of inflammatory caspases belonging to the Caspase1 (ICEtype) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase1, Caspase5 is not directly responsible for the activation of IL1Beta from the proIL1Beta precursor, but the presence of Caspase5 does appear to enhance the processing of IL1Beta. The in vivo expression of Caspase5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)induced apoptosis (1).

Attributs du produit: Phosphorylation/Apoptosis/Signal Transduction/Regulation

Purification: Purified

Immunogène: Antisera to human Caspase-5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: Western Blotting

Restrictions: For Research Use only

Stockage

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur CASP5

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Autre désignation: Caspase-5 (CASP5 Produits)

Synonymes: anticorps ICE(rel)III, anticorps ICEREL-III, anticorps ICH-3, anticorps CASP5, anticorps caspase 5, anticorps caspase-5, anticorps CASP5, anticorps LOC100437308

Pathways: Inflammasome