Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Subcellular location: Nucleus
Synonyms: Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1.