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CD45 anticorps (AA 1-100)

PTPRC Reactivité: Humain FACS, WB, IHC (p), ELISA, IHC (fro) Hôte: Souris Monoclonal 14A9 unconjugated

N° du produit ABIN6989429

Fiche de données

Antigène Voir toutes CD45 (PTPRC) Anticorps

CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
Épitope
16

16

14

13

12

10

9

7

6

6

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-100
Reactivité
372

233

88

29

20

16

15

10

7

6

6

6

4

4

3

3

2

1

1

1

1

1

1

1

1

1
Humain
Hôte
269

183

137

2

1
Souris
Anticorps secondaires appropriés
Clonalité
456

128

1
Monoclonal
Conjugué
173

54

47

47

34

15

14

12

12

11

10

10

8

8

8

6

6

6

6

5

4

4

4

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1
Cet anticorp CD45 est non-conjugé
Application
474

191

155

128

102

59

48

40

38

27

17

15

14

13

11

7

5

5

5

4

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée

Humain

Purification

Purified by Protein G.

Immunogène

Recombinant human CD45

Clone

14A9

Isotype

IgG1

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anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (C-Term) antibody
PTPRC Reactivité: Humain, Souris, Rat, Chien, Poulet, Boeuf (Vache), Cat, Lapin, Mouton, Porc, Cobaye, Chévre, Cheval, Singe, Hamster, Âne, Avian WB Hôte: Chèvre Polyclonal unconjugated

anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 378-577) antibody
PTPRC Reactivité: Humain, Souris, Rat FACS, IHC, WB, ELISA, ICC Hôte: Souris Monoclonal 2H3E2 unconjugated

anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 431-577) antibody
PTPRC Reactivité: Humain FACS, IHC, WB, ELISA, ICC, Neut Hôte: Souris Monoclonal 7C9F12 unconjugated

anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 928-989) antibody
PTPRC Reactivité: Humain IHC, WB, ELISA Hôte: Souris Monoclonal 5D3A3 unconjugated

Indications d'application

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur

ProClin

Précaution d'utilisation

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption

12 months
Antigène

CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Autre désignation

CD45 (PTPRC Produits)

Synonymes

anticorps PTPRC, anticorps si:dkeyp-47c5.1, anticorps B220, anticorps CD45, anticorps CD45R, anticorps GP180, anticorps L-CA, anticorps LCA, anticorps LY5, anticorps T200, anticorps Cd45, anticorps Ly-5, anticorps Lyt-4, anticorps loc, anticorps Lca, anticorps RT7, anticorps cd45, anticorps protein tyrosine phosphatase, receptor type C, anticorps protein tyrosine phosphatase, receptor type, C, anticorps receptor-type tyrosine-protein phosphatase C, anticorps PTPRC, anticorps ptprc, anticorps LOC100074271, anticorps Ptprc

Sujet

Synonyms: B220, CD 45, CD-45, CD45, cd45 antigen, ec3.1.3.48, CD45R, GP180, GP180, GP 180, L CA, LCA, L-CA, Leukocyte common antigen, LY5, Ly-5 glycoprotein, Protein tyrosine phosphatase receptor type C, Protein tyrosine phosphatase receptor type c polypeptide, protein tyrosine phosphatase, receptor type, C, Receptor-type tyrosine-protein phosphatase C, PTPRC, PTPRC_HUMAN, SCID due to PTPRC deficiency, T200, T200 glycoprotein, T200 leukocyte common antigen, Human homolog of severe combined immunodeficiency due to PTPRC deficiency.
Background: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

ID gène

5788

UniProt

P08575

Pathways

TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling