DFFB anticorps (AA 190-240)

N° du produit ABIN6990306

Détail du produit anti-DFFB anticorps

Antigène: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Épitope: AA 190-240

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DFFB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: DFF40 Antibody is affinity chromatography purified via peptide column.

Immunogène: DFF40 antibody was raised against a 16 amino acid peptide near the center of human DFF40. The immunogen is located within amino acids 190 - 240 of DFF40.

Isotype: IgG

Information d'application

Indications d'application: DFF40 antibody can be used for detection of DFF40 /CAD by Western blot at 0.5 - 2 μ,g/mL. dilution. A 40 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DFF40 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DFF40 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DFFB

Antigène: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Autre désignation: DFF40 (DFFB Produits)

Synonymes: anticorps CAD, anticorps CPAN, anticorps DFF-40, anticorps DFF2, anticorps DFF40, anticorps LOC100223514, anticorps 40kDa, anticorps 5730477D02Rik, anticorps Didff, anticorps Cad, anticorps carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, anticorps DNA fragmentation factor subunit beta, anticorps DNA fragmentation factor, beta polypeptide (caspase-activated DNase), anticorps DNA fragmentation factor, beta subunit, anticorps CAD, anticorps DFFB, anticorps dffb, anticorps LOC100223514, anticorps Dffb

Sujet: DFF40 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease. The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively. DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.

Poids moléculaire: Predicted: 37 kDa

Observed: 38 kDa

ID gène: 13368

NCBI Accession: NP_004393

UniProt: O54788

Pathways: Apoptose, Caspase Cascade in Apoptosis