SLC9A1 anticorps (C-Term)

N° du produit ABIN6990817

Détail du produit anti-SLC9A1 anticorps

Antigène: SLC9A1 (Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1 (SLC9A1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC9A1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: At least three isoforms of Nhe-1 are known to exist.

Purification: Nhe-1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Nhe-1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human Nhe-1. The immunogen is located within the last 50 amino acids of Nhe-1.

Isotype: IgG

Information d'application

Indications d'application: Nhe-1 antibody can be used for detection of Nhe-1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Nhe-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Nhe-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SLC9A1

Antigène: SLC9A1 (Solute Carrier Family 9, Subfamily A (NHE1, Cation Proton Antiporter 1), Member 1 (SLC9A1))

Autre désignation: Nhe-1 (SLC9A1 Produits)

Synonymes: anticorps AT-NHX1, anticorps ATNHX, anticorps ATNHX1, anticorps NA(+)/H(+) ANTIPORTER, anticorps Na+/H+ exchanger 1, anticorps T21B4.60, anticorps T21B4_60, anticorps AW554487, anticorps Apnh, anticorps Nhe1, anticorps swe, anticorps NHE-1, anticorps NHE1, anticorps APNH, anticorps Na+/H+ exchanger 1, anticorps solute carrier family 9 (sodium/hydrogen exchanger), member 1, anticorps solute carrier family 9 member A1, anticorps NHX1, anticorps Slc9a1, anticorps SLC9A1

Sujet: Nhe-1 Antibody: The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension.

Poids moléculaire: Predicted: 52, 90 kDa

Observed: 50, 90 kDa

ID gène: 6548

UniProt: P19634

Pathways: Glycosaminoglycan Metabolic Process, Proton Transport