NLRP3 anticorps (N-Term)

N° du produit ABIN6991208

Détail du produit anti-NLRP3 anticorps

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Épitope: AA 120-170, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Purification: NALP3 Antibody is affinity chromatography purified via peptide column.

Immunogène: NALP3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human NALP3. The immunogen is located within amino acids 120 - 170 of NALP3.

Isotype: IgG

Information d'application

Indications d'application: NALP3 antibody can be used for detection of NALP3 by Western blot at 1 μ,g/mL. Antibody can also be used for Immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NALP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NALP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NALP3 (NLRP3 Produits)

Synonymes: anticorps CIAS1, anticorps Nalp3, anticorps avp, anticorps cias1, anticorps nalp3, anticorps pypaf1, anticorps agtavprl, anticorps AGTAVPRL, anticorps AII, anticorps AVP, anticorps C1orf7, anticorps CLR1.1, anticorps FCAS, anticorps FCU, anticorps MWS, anticorps NALP3, anticorps PYPAF1, anticorps AII/AVP, anticorps Cias1, anticorps Mmig1, anticorps Pypaf1, anticorps NLR family pyrin domain containing-like, anticorps NLR family pyrin domain containing 3, anticorps NLR family, pyrin domain containing 3 L homeolog, anticorps NLR family, pyrin domain containing 3, anticorps NLRPL, anticorps NLRP3, anticorps nlrp3.L, anticorps Nlrp3

Sujet: NALP3 Antibody: NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1β, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-κ,B signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).

Poids moléculaire: Predicted: 101, 114 kDa

Observed: 110 kDa

ID gène: 114548

NCBI Accession: NP_899632

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome