anticorps CBR, anticorps SDR21C1, anticorps hCBR1, anticorps OPLL, anticorps AI747156, anticorps Col6a-1, anticorps RGD1565398, anticorps COL6A1, anticorps carbonyl reductase 1, anticorps collagen type VI alpha 1 chain, anticorps collagen, type VI, alpha 1, anticorps collagen, type VI, alpha 1 L homeolog, anticorps collagen type VI alpha 3 chain, anticorps collagen alpha-1(VI) chain, anticorps CBR1, anticorps COL6A1, anticorps Col6a1, anticorps col6a1.L, anticorps COL6A3, anticorps col6a1, anticorps LOC100623720
Sujet
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.