NRF2 anticorps
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- Antigène Voir toutes NRF2 (NFE2L2) Anticorps
- NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
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Reactivité
- Humain, Rat, Souris, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NRF2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS)
- Purification
- Immunogen affinity purified
- Pureté
- ≥95 % as determined by SDS-PAGE
- Immunogène
- nuclear factor(erythroid-derived 2)-like 2
- Isotype
- IgG
- Top Product
- Discover our top product NFE2L2 Anticorps primaire
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- Indications d'application
- WB: 1:200-1:2000, IP: 1:200-1:1000, IHC: 1:50-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Date de péremption
- 12 months
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- Antigène
- NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
- Autre désignation
- NRF2, NFE2L2 (NFE2L2 Produits)
- Synonymes
- anticorps Nrf2, anticorps nfe2l2, anticorps wu:fc15g09, anticorps wu:fj67e03, anticorps NF-E2R2, anticorps NRF2, anticorps AI194320, anticorps nuclear factor, erythroid 2-like 2a, anticorps nuclear factor, erythroid 2 like 2 S homeolog, anticorps nuclear factor, erythroid 2 like 2, anticorps nuclear factor, erythroid derived 2, like 2, anticorps nuclear factor, erythroid 2-like 2, anticorps nfe2l2a, anticorps nfe2l2.S, anticorps NFE2L2, anticorps Nfe2l2
- Sujet
- Synonyms:HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2 Background:NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.
- Poids moléculaire
- 70-100 kDa
- ID gène
- 4780
- UniProt
- Q16236
- Pathways
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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