MAPK7 anticorps (Mitogen-Activated Protein Kinase 7) (AA 725-740) (Cy5)

Details for Product anti-MAPK7 Antibody No. ABIN710280
Antigène
  • BMK1
  • ERK4
  • ERK5
  • PRKM7
  • Erk5-T
  • ATMPK7
  • F8D23.5
  • F8D23_5
  • MAP kinase 7
  • Bmk1
  • Erk5
  • Prkm7
  • ERK-5
  • bmk1
  • erk4
  • mapk7
  • prkm7
  • mitogen-activated protein kinase 7
  • MAP kinase 7
  • mitogen-activated protein kinase 7 L homeolog
  • MAPK7
  • Mapk7
  • MPK7
  • mapk7.L
Épitope
AA 725-740, pSer731, pThr733
18
16
16
15
15
15
15
14
13
7
6
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
222
145
133
3
2
2
2
2
2
1
Hôte
Lapin
195
24
3
2
Clonalité
Polyclonal
Conjugué
Cet anticorp MAPK7 est conjugé à/à la Cy5
11
8
8
8
8
8
8
8
7
5
5
5
5
5
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
137
65
52
44
27
25
22
8
3
2
2
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation sites of Ser731+Thr733
Isotype IgG
Specificité Recognizes Ser721+Thr723 in mice and rats
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MAPK7 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Erk5 (MAPK7 Antibody Extrait)
Sujet

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Subcellular location: Cytoplasm, Nucleus

Synonyms: BMK1, ERK4, ERK5, PRKM7, Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5, MAPK7

ID gène 5598
UniProt Q13164
Pathways Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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