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FLT4 anticorps (AA 901-1000) (Cy5)

FLT4 Reactivité: Humain, Souris IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN737410
  • Antigène Voir toutes FLT4 Anticorps
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Épitope
    • 16
    • 13
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 901-1000
    Reactivité
    • 84
    • 50
    • 16
    • 11
    Humain, Souris
    Hôte
    • 72
    • 27
    • 9
    • 2
    Lapin
    Clonalité
    • 73
    • 37
    Polyclonal
    Conjugué
    • 58
    • 11
    • 7
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FLT4 est conjugé à/à la Cy5
    Application
    • 57
    • 43
    • 38
    • 30
    • 15
    • 13
    • 13
    • 10
    • 9
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from mouse VEGFR3
    Isotype
    IgG
    Top Product
    Discover our top product FLT4 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Autre désignation
    VEGFR3 (FLT4 Produits)
    Synonymes
    anticorps FLT41, anticorps LMPH1A, anticorps PCL, anticorps VEGFR3, anticorps AI323512, anticorps Chy, anticorps Flt-4, anticorps VEGFR-3, anticorps Vegfr3, anticorps cb1059, anticorps fms related tyrosine kinase 4, anticorps FMS-like tyrosine kinase 4, anticorps fms-related tyrosine kinase 4, anticorps FLT4, anticorps Flt4, anticorps flt4
    Sujet

    Synonyms: Chy, Flt-4, VEGFR3, VEGFR-3, AI323512, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, Flt4

    Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

    ID gène
    14257
    UniProt
    P35917
    Pathways
    Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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