c-MET anticorps (AA 208-407) (APC)

N° du produit ABIN8009294

Cet anticorps Lapin Polyclonal détecte spécifiquement c-MET dans FACS. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour c-MET anticorps (AA 208-407) (APC) (ABIN8009294)

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MET est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-c-MET anticorps (APC)

Épitope: AA 208-407

Fonction: Anti-Met (c-Met) Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human Met shares 90%,91% amino acid (aa) sequences identity with mouse,rat Met,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: MET

Sujet:

Background: c-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.

Gene Full Name: MET proto-oncogene, receptor tyrosine kinase

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.

ID gène: 4233

UniProt: P08581

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor