Prostaglandin D2 Receptor 2 (PTGDR2) (N-Term) anticorps

N° du produit ABIN783548

Détail du produit

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide from near the amino terminus of human CRTH2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détail du antigène

Antigène: Prostaglandin D2 Receptor 2 (PTGDR2)

Autre désignation: CD294 / GPR44 (PTGDR2 Produits)

Synonymes: anticorps CD294, anticorps CRTH2, anticorps DL1R, anticorps DP2, anticorps GPR44, anticorps Crth2, anticorps Grp45, anticorps Ptgdr2, anticorps Gpr44, anticorps prostaglandin D2 receptor 2, anticorps PTGDR2, anticorps Ptgdr2

Sujet: The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.Synonyms: CRTH2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, DL1R, Putative G-protein coupled receptor 44

ID gène: 11251

NCBI Accession: NP_004769

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling