STAT6 anticorps

N° du produit ABIN920869

Détail du produit anti-STAT6 anticorps

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT6 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes STAT6.

Purification: Purified by antigen-affinity chromatography.

Immunogène: Peptide mapped to the carboxy-terminus of human STAT6.

Information d'application

Indications d'application: Western blot: Use at 10 myL per 5 mL antibody dilution buffer for each mini-gel.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 200 µL containing rabbit IgG in PBS, pH 7.2, with 0.09% sodium azide and 50% glycerol and protein stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur STAT6

Antigène: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Autre désignation: STAT6 (STAT6 Produits)

Synonymes: anticorps D12S1644, anticorps IL-4-STAT, anticorps STAT6B, anticorps STAT6C, anticorps signal transducer and activator of transcription 6, anticorps signal transducer and activator of transcription 6-like, anticorps STAT6, anticorps Stat6, anticorps LOC100859543

Sujet: STAT6 is a 94 kD member of the STAT (signal transducer and activator of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT6 induces nuclear translocation to activate transcription. STAT6 is expressed in olfactory cells, bronchial epithelium, adrenal gland, B cells, mast cells, Wilm's tumors and some solid tumors. STAT6 forms homo- and heterotrimers and has been shown to be important in IL-4 mediated biological responses, the induction of Bcl-2 and Bcl-XL, and may also be involved in TH2 differentiation and immunoglobulin class switching. STAT6 is phosphorylated in response to IL-4, IL-13, IL-3 and has been shown to interact with nuclear co-activator 1 (NCOA1), the CREB binding SRC-1 protein, and p300/CBP. Synonyms: Anti-signal transducer and activator of transcription 2, anti-interferon alpha induced transcriptional activator.

Poids moléculaire: 94 kDa

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response