HLA-DQA1 anticorps (Middle Region)

N° du produit ABIN952750

Détail du produit anti-HLA-DQA1 anticorps

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Épitope: AA 56-84, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DQA1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes Human HLA class II DQ alpha 1 / HLA-DQA1 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 56-84 amino acids from the Central region of Human HLA class II DQ alpha 1 / HLA-DQA1

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HLA-DQA1

Antigène: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Abstract: HLA-DQA1 Produits

Synonymes: anticorps CD, anticorps CELIAC1, anticorps DQ-A1, anticorps GSE, anticorps HLA-DQA, anticorps BoLA-DQA, anticorps hla-dqa1, anticorps major histocompatibility complex, class II, DQ alpha 1, anticorps major histocompatibility complex, class II, DQ alpha, type 1, anticorps major histocompatibility complex, class II, DQ alpha 1 L homeolog, anticorps HLA-DQA1, anticorps BOLA-DQA1, anticorps hla-dqa1.L

Sujet: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.Synonyms: DC-1 alpha chain, DC-alpha, HLA class II histocompatibility antigen DQ(3) alpha chain, HLA-DCA, MHC class II DQA1

Poids moléculaire: 27805 Da

ID gène: 100133678

NCBI Accession: NP_002113

Pathways: TCR Signaling, Cancer Immune Checkpoints