SETD2 anticorps (Internal Region)

N° du produit ABIN954755

Détail du produit anti-SETD2 anticorps

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-ERDPDKQTQN KE

Specificité: This antibody recognizes HYPB / SETD2 (internal region).

Réactivité croisée (Details): Species reactivity (expected):Human.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_054878.3. Genename: SETD2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SETD2

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Autre désignation: SETD2 / HIF1 (SETD2 Produits)

Synonymes: anticorps Kif9, anticorps HBP231, anticorps HIF-1, anticorps HIP-1, anticorps HYPB, anticorps KMT3A, anticorps SET2, anticorps p231HBP, anticorps SET domain containing 2, anticorps Setd2, anticorps SETD2

Sujet: SET2 is a Histone methyltransferase that methylates 'Lys-36' of Histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.Synonyms: HIF-1, HIP-1, HIP1, HYPB, Histone-lysine N-methyltransferase SETD2, Huntingtin yeast partner B, Huntingtin-interacting protein 1, Huntingtin-interacting protein B, KIAA1732, KMT3A, Lysine N-methyltransferase 3A, SET domain-containing protein 2, SET2, p231HBP

ID gène: 29072

NCBI Accession: NP_054878

Pathways: Tube Formation