GSK3 alpha anticorps

N° du produit ABIN966229

Cet anticorps not_set Monoclonal détecte spécifiquement GSK3 alpha dans WB, IHC et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour GSK3 alpha anticorps (ABIN966229)

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp GSK3 alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-GSK3 alpha anticorps

Specificité: Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-GSK3 alpha (ABIN966229)

Sayas, Ariaens, Ponsioen, Moolenaar: "GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction." dans: Molecular biology of the cell, Vol. 17, Issue 4, pp. 1834-44, (2006) (PubMed).

Bradley, Currie, MacMillan, Muir, McCarron: "Cyclic ADP-ribose increases Ca2+ removal in smooth muscle." dans: Journal of cell science, Vol. 116, Issue Pt 21, pp. 4291-306, (2003) (PubMed).

Détails sur GSK3 alpha

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Autre désignation: GSK3 alpha

Sujet: GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.

ID gène: 11076

Pathways: Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, L'effet Warburg