GSK3 alpha anticorps

N° du produit ABIN966230

Il existe 3+ publications pour ce produit. L’anticorps anti-GSK3 alpha Monoclonal est utilisé pour la détection de GSK3 alpha dans des échantillons de Humain. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour GSK3 alpha anticorps (ABIN966230)

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp GSK3 alpha est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-GSK3 alpha anticorps

Specificité: Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
IF:1: 200- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-GSK3 alpha (ABIN966230)

Mendez, Garcia-Segura: "Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells." dans: Endocrinology, Vol. 147, Issue 6, pp. 3027-39, (2006) (PubMed).

Bianchi, De Lucchini, Marin, Turner, Hanks, Villa-Moruzzi: "Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration." dans: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 359-70, (2005) (PubMed).

De Servi, Hermani, Medunjanin, Mayer: "Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells." dans: Oncogene, Vol. 24, Issue 31, pp. 4946-55, (2005) (PubMed).

Détails sur GSK3 alpha

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Autre désignation: GSK3 alpha

Sujet: Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

ID gène: 11076

Pathways: Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, L'effet Warburg