WNT5A anticorps

N° du produit ABIN967259

Détail du produit anti-WNT5A anticorps

Antigène: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WNT5A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human XBP1 expressed in E. Coli.

Clone: 6F2

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-WNT5A (ABIN967259)

Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: "Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1." dans: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14904-13, (2009) (PubMed).

Schardt, Weber, Eyholzer, Mueller, Pabst: "Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 11, pp. 3834-41, (2009) (PubMed).

Détails sur WNT5A

Antigène: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Autre désignation: WNT5A (WNT5A Produits)

Synonymes: anticorps hWNT5A, anticorps wnt-5A, anticorps wnt5a-B, anticorps WNT5A, anticorps 8030457G12Rik, anticorps Wnt-5a, anticorps Wnt family member 5A, anticorps Wnt family member 5A S homeolog, anticorps wingless-type MMTV integration site family, member 5a, anticorps wingless-type MMTV integration site family, member 5A, anticorps wingless-related MMTV integration site 5A, anticorps Wnt signaling ligand, anticorps WNT5A, anticorps Wnt5a, anticorps wnt5a.S, anticorps wnt5a, anticorps LOC578814, anticorps wnt5

Sujet: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Synonyms: hWNT5A

Poids moléculaire: 42.3kDa

ID gène: 7474

Pathways: Signalisation WNT, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size, Tube Formation