Profil protéine

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with GRM8

• glutamate metabotropic receptor 8 (GRM8) anticorps
• metabotropic glutamate receptor 8 (MGLUR8) anticorps
• metabotropic glutamate receptor 8 (LOAG_14062) anticorps
• glutamate receptor, metabotropic 8 (Grm8) anticorps
• glutamate metabotropic receptor 8 (Grm8) anticorps

• A230002O04 anticorps
• Glur8 anticorps
• Gprc1h anticorps
• GRM8 anticorps
• mGlu8 anticorps
• Afficher tous les alias de synonymes
• mGlur anticorps
• Mglur8 anticorps
• mGluR8b anticorps

Protein level used designations for GRM8

metabotropic glutamate receptor 8 , metabotropic type glutamate receptor 8 , glutamate receptor, metabotropic 8 , G protein coupled receptor, family C, group 1, member H , G protein-coupled receptor, family C, group 1, member H , G protein-coupled receptor family C group 1 member H , metabotropic glutamate receptor subtype 8b