CD59 Produits
(CD59)
Catégories
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Catégories CD59 en vedette
CD59 Anticorps
High quality antibodies with extensive validation data.
CD59 Kits ELISA
Reliable ELISA kits for a wide range of species.
CD59 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CD59 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
FACS, WB, IHC, ELISA, ICC
Validations
- (2)
- (8)
N° du produit
ABIN1098134
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
FACS, WB, IF, IHC (p)
Validations
- (5)
N° du produit
ABIN6242239
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
FACS, IP, IHC (p)
Validations
- (4)
- (4)
N° du produit
ABIN94199
Quantité
0.1 mg
Fiche technique
Fiche technique
CD59 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6960667
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965599
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965598
Quantité
96 tests
Fiche technique
Fiche technique
CD59 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7274197
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Human Cells
Validations
- (1)
N° du produit
ABIN7319910
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122212
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CD59
: "Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT." dans: Molecular biotechnology, (2018) (PubMed).: "A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model." dans: PLoS ONE, Vol. 12, Issue 4, pp. e0174074, (2017) (PubMed).
: "Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation." dans: Scientific reports, Vol. 6, pp. 26274, (2016) (PubMed).
: "The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events." dans: Cell metabolism, Vol. 19, Issue 5, pp. 883-90, (2014) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" dans: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
: "Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease." dans: Journal of internal medicine, Vol. 276, Issue 5, pp. 470-85, (2014) (PubMed).
: "Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells." dans: Chembiochem : a European journal of chemical biology, Vol. 15, Issue 10, pp. 1393-8, (2014) (PubMed).
: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." dans: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).
: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." dans: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).
: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." dans: International immunology, Vol. 19, Issue 5, pp. 675-84, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à CD59
CD59 molecule (CD59 blood group) (CD59), CD59 molecule (Cd59), CD59 molecule (CD59), 1F5, 16.3A5, Cd59a, Cd59b, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MACIP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20Protein level used designations for CD59
- 1F5 antigen
- 20 kDa homologous restriction factor
- CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
- CD59 glycoprotein
- Ly-6-like protein
- MEM43 antigen
- T cell-activating protein
- human leukocyte antigen MIC11
- lymphocytic antigen CD59/MEM43
- membrane attack complex (MAC) inhibition factor
- membrane attack complex inhibition factor
- membrane inhibitor of reactive lysis
- protectin
- surface anitgen recognized by monoclonal antibody 16.3A5
- CD59 antigen
- CD59b moleucle, complement regulatory protein
- Cb59b molecule
- MAC-inhibitory protein
- MAC-IP
- MACIF
- CD59 homolog
- CD59 molecule, complement regulatory protein
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