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Human Polyclonal AIRE Primary Antibody pour IHC, ELISA - ABIN185643
Niki, Oshikawa, Mouri, Hirota, Matsushima, Yano, Han, Bando, Izumi, Matsumoto, Nakayama, Kuroda, Matsumoto: Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. dans The Journal of clinical investigation 2006
Show all 3 Pubmed References
Human Polyclonal AIRE Primary Antibody pour IHC (p), ELISA - ABIN546881
Kumar, Laloraya, Wang, Ruan, Davoodi-Semiromi, Kao, She: The autoimmune regulator (AIRE) is a DNA-binding protein. dans The Journal of biological chemistry 2001
Cow (Bovine) Polyclonal AIRE Primary Antibody pour WB - ABIN2779776
Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. dans Molecular immunology 2005
Genetic model analysis showed significant correlations between the TT genotype and the risk of rheumatoid arthritis. Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased rheumatoid arthritis risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.
Direct interactions between AIRE, NF-kappaB, and P-TEFb result in efficient transcription of their target genes.
this review shows the role of AIRE in peripheral tolerance
AIRE contributes to autoimmunity in more common organ-specific autoimmune disorders than autoimmune polyendocrine syndrome type-1 (Review)
Rs3761389 variant is associated with the susceptibility of myasthenia gravis in Chinese patients.
Our findings suggest that AIRE does not have a role in the induction and function of monocyte-derived tolerogenic DC in humans, but these findings do not exclude a role for AIRE in peripheral tolerance mediated by other cell types.
Estrogen induces decreased thymic AIRE expression by epigenetic modifications through increased number of methylation sites within the AIRE promoter.[review]
Whole exome sequencing followed by Sanger sequencing revealed that all three subjects affected by hypoparathyroidism were compound heterozygous for two previously reported mutations, c.967_979delCTGTCCCCTCCGC:p.(L323SfsX51) and c.995+(3_5)delGAGinsTAT, in AIRE, which encodes the autoimmune regulator protein that is defective in autoimmune polyglandular syndrome type 1 (APS-1).
Aire exerts multi-faceted autoimmune control that extends to a population of innate-like T cells.
Homozygote Mutation in the AIRE gene is associated with APECED syndrome.
the presence of AIRE can trigger molecular events leading to an altered chromatin landscape and the enhanced transcription of low-expressed genes
These data are the first to identify AIRE expression in breast cancer and an association with prognosis.
AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity.
this paper shows that genetic polymorphisms in AIRE do not contribute to the Graves' disease in Spain
This study supports the notion that AIRE mutation could specifically affect human insulin gene expression in thymic epithelial cells through INS-VNTR and subsequently induce either insulin tolerance or autoimmunity.
androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.
results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases.
The rs2075876 and rs760426 loci of the AIRE gene are associated with increased risk for rheumatoid arthritis among ethnic Han Chinese from ShaanXi.
The novel mutation of c.622G>T (p.G208W) in AIRE gene is associated autoimmune polyendocrinopathy syndrome type I.
AIRE-655GAIRE-230T haplotype could dramatically alter AIRE transcription.
At 5 weeks of age (wk), Aire-/- mice show minimal tissue dysfunction and destruction compared to 7 wk Aire-/-, which exhibit severe dry eye, poor tear secretion, extensive lymphocytic infiltration, reduced functional innervation, and increased vascularization.
This study re-defines requirements for late stage intrathymic alphabetaT-cell development, and demonstrates that Aire controls a CCR6-CCL20 axis that determines the developmental makeup of the intrathymic regulatory T-cell pool.
The Aire fl/fl strain is a suitable model to scrutinize the cell specific function of Aire in distinct biological processes. Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Aire was also shown to be expressed in cells of hematopietic and reproductive lineages.
Aire associates with spindle-associated proteins in mouse embryonic stem cells. Loss of function analysis revealed that Aire was important for centrosome number regulation and spindle pole integrity specifically in mouse embryonic stem cells.
allelic variants of one AIRE SNP may differentially shape the melanoma antigen-specific T cell repertoire potentially influencing susceptibility to melanoma
In an insulin-promoter model, lack of Aire in medullary thymic epithelial cells, but not in BM-derived APCs, impaired clonal deletion and Treg production. In an Aire-promoter Tg model, both mTECs and BM-derived APCs independently induced clonal deletion without Aire. Treg production was impaired by the lack of Aire in mTECs, but not in BM-derived APCs, suggesting an essential but not universal role for Aire in tolerance.
the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression
A mutation in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, combines with an Aire mutation to provoke organ-specific autoimmunity.
this study shows that Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage
This finding is the first direct evidence that Aire also plays a role in controlling medullary thymic epithelial cells-thymocyte adhesion.
findings identified two novel stages in the differentiation program of Aire(+) Medullary thymic epithelial cells.
this study shows that Aire and some of its partners, notably those implicated in the DNA-damage response, preferentially localize to and activate long chromatin stretches that are overloaded with transcriptional regulators, known as super-enhancers
Results indicated that AIRE influenced gene expression in germ cell 1 spermatogonial (GC1-spg) cells by acting at multiple levels, including transcription, translation, RNA processing, protein transport, protein localization, and protein degradation, thus setting the foundation in understanding the functional role of AIRE in germ cell biology.
this study provides insight into the complex molecular mechanisms that control the medullary thymic epithelial cells-specific expression of Aire
we found that Aire up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB) of the TLR3 signaling pathway.
Aire-expressing dendritic cells inhibited TCR signaling pathways and decreased quantity of CD4+IFN-gamma+ autoreactive T cells. Aire plays role in maintenance of peripheral immune tolerance.
Aire may have a role in inducing Th1 and Th17 differentiation by upregulating cytokine expression in dendritic cells.
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
, APECED protein homolog
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
, autoimmune regulator AIRE1a