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Human Polyclonal PCGF2 Primary Antibody pour ELISA, WB - ABIN249894
Ishida, Asano, Hasegawa, Koseki, Ono, Yoshida, Taniguchi, Kanno: Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. dans Gene 1993
Low expression of Mel-18 is correlated with gastric cancer.
Suggest a novel role of PCGF2 in arsenic trioxide-mediated degradation of PML (Montrer PML Anticorps)-RARA (Montrer RARA Anticorps) that PCGF2 might act as a negative regulator of UBE2I (Montrer UBE2I Anticorps) via direct interaction.
Mel-18 underexpression in luminal breast cancer cells caused ER-alpha (Montrer ESR1 Anticorps) downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 (Montrer ESR1 Anticorps) transactivators p53 (Montrer TP53 Anticorps) and SP1 (Montrer PSG1 Anticorps).
It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression.
Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer.
Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt (Montrer WNT2 Anticorps)-mediated Notch (Montrer NOTCH1 Anticorps) signaling.
PCGF2, a PRC1 (Montrer PRC1 Anticorps) gene, played a negative role in the granulocytic differentiation of human APL (Montrer FASL Anticorps) cells.
these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha (Montrer HIF1A Anticorps) and its target VEGF (Montrer VEGFA Anticorps) expressions mediated by the PTEN/PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
Loss of Mel-18 is associated with prostate cancer.
Our analysis showed correlation between BMI1 (Montrer BMI1 Anticorps) and PCGF2 gene's expression and survival in children with medulloblastoma.
BMI1 (Montrer BMI1 Anticorps) and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b (Montrer REG3B Anticorps). REG3B (Montrer REG3B Anticorps) negatively regulates cytokine-induced activation of STAT3 (Montrer STAT3 Anticorps) in colon epithelial cells.
Data indicate that Bmi1 (Montrer BMI1 Anticorps) and Mel18 have opposing functions and are present in distinct complexes.
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Data show that Mel-18 and Ezh2 (Montrer EZH2 Anticorps) positively regulate the expression of Il17a (Montrer IL17A Anticorps) and Il17f (Montrer IL17F Anticorps).
Chemokine (Montrer CCL1 Anticorps)-mediated thymopoiesis is regulated by a mammalian Polycomb (Montrer CBX2 Anticorps) group gene, mel-18
the stoichiometry and/or equilibrium of subunits of the class II Polycomb complex containing Mel-18 might be regulated by changes in phosphorylation status via the PKC signaling pathway
Results provide genetic evidence that Cited2 controls the expression of INK4a/ARF and fibroblast proliferation, at least in part via the polycomb-group genes Bmi1 and Mel18.
Loss or knockdown of mel-18 leads to the expression of Hoxb4 (Montrer HOXB4 Anticorps), an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC (Montrer FUT1 Anticorps) self-renewal.
Mel-18 contributes to the maintenance of the active state of the Hes-1 (Montrer HES1 Anticorps) gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
Sf3b1 (Montrer SF3B1 Anticorps)-Zfp144 protein interaction is essential for true Polycomb (Montrer CBX2 Anticorps) group proteins mediated repression of Hox (Montrer MSH2 Anticorps) genes.
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
polycomb group RING finger protein 2
, zinc finger protein 144 (Mel-18) (human homolog)
, polycomb group ring finger 2
, ring finger protein 110
, DNA-binding protein Mel-18
, zinc finger protein 144
, melanoma nuclear protein 18