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anti-Human ERN1 Anticorps:
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Human Polyclonal ERN1 Primary Antibody pour ELISA, ICC - ABIN250706
Lipson, Fonseca, Ishigaki, Nguyen, Foss, Bortell, Rossini, Urano: Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. dans Cell metabolism 2006
Show all 183 Pubmed References
Human Polyclonal ERN1 Primary Antibody pour ICC, IF - ABIN250711
Kubota, Lee, Tsuchiya, Young, Everett, Martinez-Mier, Snead, Nguyen, Urano, Bartlett: Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. dans The Journal of biological chemistry 2005
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Human Polyclonal ERN1 Primary Antibody pour IF (p), IHC (p) - ABIN1387555
Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. dans Neuroscience 2014
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Polyclonal ERN1 Primary Antibody pour WB - ABIN540729
Katoh, Katoh: Identification and characterization of JMJD2 family genes in silico. dans International journal of oncology 2004
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Polyclonal ERN1 Primary Antibody pour WB - ABIN540727
Fonseca, Fukuma, Lipson, Nguyen, Allen, Oka, Urano: WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. dans The Journal of biological chemistry 2005
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Human Monoclonal ERN1 Primary Antibody pour IHC, ELISA - ABIN969116
Huang, Tan, Yoshida, Mori, Ma, Yen: Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. dans Molecular and cellular biology 2005
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Human Polyclonal ERN1 Primary Antibody pour ELISA, WB - ABIN1002690
Little, Ramakrishnan, Roy, Gazit, Lee: The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. dans Critical reviews in eukaryotic gene expression 1995
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Human Polyclonal ERN1 Primary Antibody pour ICC, ELISA - ABIN1002689
Bertolotti, Zhang, Hendershot, Harding, Ron: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. dans Nature cell biology 2000
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Human Polyclonal ERN1 Primary Antibody pour ICC, ELISA - ABIN1002688
Shen, Chen, Hendershot, Prywes: ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. dans Developmental cell 2002
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IRE1-XBP1 silencing also inhibited radiation-induced IL-6 expression.
Glucocorticoid-induced endoplasmic reticulum stress activated the IRE1alpha/XBP-1s signaling.
Suggest an unanticipated biological function of IRE1alpha in cell migration, whereby filamin A operates as an interphase between the UPR and the actin cytoskeleton.
ovarian cancer--an aggressive malignancy that is refractory to standard treatments and current immunotherapies--induces endoplasmic reticulum stress and activates the IRE1alpha-XBP1 arm of the unfolded protein response in T cells to control their mitochondrial respiration and anti-tumour function
Coordination between two branches of the unfolded protein response determines apoptotic cell fate so that PERK attenuates IRE1 via RPAP2 to abort failed endoplasmic reticulum stress adaptation and trigger apoptosis.
While PERK complexes shift to large complexes, ATF6alpha complexes are reduced to smaller complexes on endoplasmic reticulum (ER) stress. In contrast, IRE1alpha complexes were not significantly increased in size on ER stress, unless IRE1alpha is overexpressed.
This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression.
IRE1alpha acts in a feed-forward loop during obesity-induced metabolic inflammation to promote hepatocellular carcinoma development through STAT3-mediated hepatocyte proliferation
necrotic cell lysates induce JNK/SAPK signaling, the IRE1alpha branch of the unfolded protein response (UPR), the MAPK/ERK1/2, and the mTOR signaling pathways and results in an enhanced proliferation of the vital surrounding cells.
Data show that breast cancer cells exhibit constitutive serine/threonine-protein kinase/endoribonuclease IRE1 (IRE1) RNase activity.
results suggest that apocynin protects ECs against ER stress-induced apoptosis via IRE1alpha involvement. These findings may provide a novel mechanistic explanation for the anti-apoptotic effect of apocynin in ER stress.
Study results provide evidence that DDRGK1 is essential for endoplasmic reticulum (ER) homeostasis regulation in both human cancer cells and mouse hematopoietic stem cells. Depletion of DDRGK1 activates apoptotic pathway by targeting the ER-stress sensor IRE1alpha. DDRGK1 regulates IRE1alpha protein stability via its interaction with the kinase domain of IRE1alpha.
IRE1 was up-regulated during excisional wound healing at the time in wound healing consistent with that of the proliferative phase. Inhibition of IRE1 led to decreased scar formation.
urinary levels of the spliced X-box binding protein 1 (sXBP1) mRNA as a proxy of inositol-requiring enzyme 1alpha (IRE1alpha) activity because sXBP1 is absolutely sensitive and specific for endoplasmic reticulum stress.
Here, the authors show that similar to yeast, human IRE1alpha's endoplasmic reticulum-lumenal domain (hIRE1alpha LD) binds peptides with a characteristic amino acid bias. Peptides and unfolded proteins bind to hIRE1alpha LD's MHC-like groove and induce allosteric changes that lead to its oligomerization.
Three branches of the Unfolded Protein Response (UPR) have been described, including the activation of the inositol-requiring enzyme 1 (IRE1), the pancreatic ER kinase (PKR)-like ER kinase (PERK), and the activating transcription factor 6 (ATF6).
IRE1alpha is expressed at lower levels in higher-grade gliomas, suggesting greater antitumor efficacy of the oncolytic virus M1. Taken together, these findings illustrate a defensive mechanism of glioma cells against the oncolytic virus M1 and identify possible approaches to enhance the oncolytic viral protein accumulation and the subsequent lysis of tumor cells.
Systematic mutation of the AREs (ARE1-3) in the LDLR 3'UTR and expression of each mutant coupled to a luciferase reporter in Huh7 cells demonstrated that ARE1 is required for rapid LDLR mRNA decay and 5-AzaC-induced mRNA stabilization via the IRE1alpha-EGFR-ERK1/2 signaling cascade.
Pharmacologic modulation of IRE1 counteracts metaflammation and alleviates atherosclerosis.
Present study demonstrates that fine-tuning of the expression of proliferation related transcription factor genes depends upon glucose and glutamine deprivation in IRE1-dependent manner and possibly contributes to slower tumor growth after inhibition of IRE1.
The authors found that estrogen signals through estrogen receptor alpha (ERalpha) expressed in hematopoietic cells to activate the protective Ire1alpha-Xbp1 branch of the unfolded protein response.
These observations were validated in vivo in the liver of IRE1a conditional knockout mice, revealing broad implications for cellular metabolism. Our results support an alternative function of IRE1alphaain orchestrating the communication between the endoplasmic reticulum and mitochondria to sustain bioenergetics
IRE1 undergoes phosphorylation at S729.
These findings provide a novel mechanism by which XBP1s stimulate insulin sensitivity in adipocytes through fibroblast growth factor 21 induction and PPARgamma activation.
Inositol-requiring protein 1 ire1-alpha (IRE1alpha)-X-box binding protein 1 (XBP1) protect haematopoietic stem cells (HSC) from endoplasmic reticulum stress-induced apoptosis.
stimulates mitochondrial permeability transition pore excessive opening, causing endoplasmic reticulum stress through p38 mitogen-activated protein kinase activation, resulting in enhanced sterol regulatory element-binding protein-1c transcription and hepatic steatosis
IRE1alpha-XBP1 pathway plays an important role in the efficient folding of proinsulin and transcriptional induction of the five PDI family proteins, which are critical for correct disulfide bond formation of proinsulin, in pancreatic beta cells.
Targeting IRE1alpha-dependent NLRP3 inflammasome signaling with pharmacological agents or by BI-1 may represent a tangible therapeutic strategy for nonalcoholic steatohepatitis
an IRE1alpha-dependent signaling cascade couples constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated invariant natural killer T cells.
It has been proposed that SelS promoted cell survival through the IRE1a-XBP1 signaling pathway.
IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a strategy for treatment of colon cancers.
Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC) neuronal IRE1alpha function. The effects of POMC IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC neurons plays a critical role in the regulation of obesity and obesity-related m...
Data show that LPS induces endoplasmic reticulum (ER) stress and P300 activity via the XBP1/IRE1 pathway.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
Data suggest that activation of GRP78/Ire1/Xbp1 pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
ER to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 1
, inositol-requiring 1
, inositol-requiring enzyme 1
, inositol-requiring protein 1
, protein kinase/endoribonuclease
, serine/threonine-protein kinase/endoribonuclease IRE1
, endoplasmic reticulum to nucleus signalling 1
, inositol-requiring 1 alpha
, endoplasmic reticulum (ER) to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, endoplasmic reticulum to nucleus signaling 1