Aperçu des produits pour anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Anticorps

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

1. Anti-PD-1 and anti PDL-1 do not increase the formation of ADA, but anti-CTLA-4 and anti-OX-40 do increase the onset of ADA.

2. The authors established that OX40L/OX40 interaction was required and sufficient to induce regulatory T-cell proliferation in vivo independent of PKC- status. Although PKC- is dispensable for T-cell receptor-independent regulatory T-cell proliferation per se, it is essential for optimum IL-2 production by effector T-cells.

3. Crucial role of OX40/OX40L signaling in a murine model of asthma has been demonstrated.

4. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects

5. High Fat Diet-induced obese mice exhibit increased OX40 expression in adipose tissues and splenic T cells.

6. These data support the hypothesis that the Ox40/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus.

7. OX40 is a death receptor for invariant natural killer T cells and is implicated in pyroptotic cell death.

8. this study shows that OX40 links a costimulatory receptor to a repressive chromatin remodeling pathway, and that that OX40 stimulation inhibits IL-17 and reduces experimental autoimmune encephalomyelitis

9. IFNalphaR1 signaling promoted CXCL9 and CXCL10 synthesis, suggesting that these chemokines might be involved in the LPS and CD134 costimulation response.

10. OX40 and ICOS act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection

11. OX40 regulates cardiac remodelling via the modulation of CD4(+) T-lymphocytes.

12. bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4+ T cells to Th2 cells by ligation of OX40L and OX40 between BMMC-exosomes and CD4+ T cells and represents a novel mechanism of cell-to-cell communication

13. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.

14. The OX40-OX40 ligand interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis.

15. OX40 was highly expressed by intratumoral T cells, particularly those of the FoxP3(+) regulatory T-cell (Treg) lineage.

16. OX40 and IL-7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T cells

17. OX40-OX40L interaction regulates the expression of NFATc1, which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.

18. During CD134 plus CD137 dual costimulation, IFN-gamma interacts with IL-2 through distinct mechanisms to program maximal expression of effector molecules in antigen-responding T-cells.

19. OX40 stimulation of virus-specific CD4 T cells promoted expression of the transcriptional repressor Blimp-1 and diverted the majority of cells away from follicular Th cell differentiation.

20. interruption of the OX40-OX40L signaling pathway, with decreases in dietary cholesterol, induces regression of atherosclerosis by induction of IL-5-producing T cells and oxidized low-density lipoprotein-specific IgM and reductions in Th2 and mast cells.

Human Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

1. increased expression levels of OX40 and OX40L were involved in the pathogenesis of Immune thrombocytopenia

2. Authors report that OX40 is expressed on leukemic blasts in a substantial percentage of patients with acute myeloid leukemia (AML) and that OX40 can, after stimulation with agonistic OX40 antibodies, mediate proliferation and release of cytokines that act as growth and survival factors for the leukemic cells.

3. High OX40 expression in Ovarian carcinoma is correlated with chemosensitivity and improved recurrence free survival in Ovarian carcinoma . Patients might therefore benefit from a second line therapy.

4. Increased OX40 expression is associated with gastric cancer.

5. this study demonstrates that cSCCs contain an abundance of Tregs which can suppress tumoral effector T cell function and that activation of the costimulatory receptor OX40 enhances tumoral T cell responses.

6. OX40 expression on T cells was positively associated with obesity in humans.

7. Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection.

8. OX40 and OX40L formed a functional complex, which may facilitate signal transduction from OX40L to OX40 and contribute to the pathogenesis of Grave's disease.

9. this study investigated whether CD134 is preferentially expressed on CD4 T cells in drug-induced hypersensitivity syndrome .

10. blocking of both OX-40L and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.

11. Low OX40 expression is associated with colorectal cancer.

12. OX40 and its ligand are co stimulators for T lymphocytes.

13. These studies provide the first direct evidence that ligation of tumour necrosis factor superfamily members and their cognate receptors is important for the control of viral lytic replication.

14. Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 T cells, which is abrogated following coordinate PD-1 co-inhibitory pathways, which are also upregulated during malaria.

15. Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134.

16. TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells

17. contributes to the aberrant T Follicular Helper response in systemic lupus erythematosus

18. Data indicate that soluble OX40 and sOX40L plasma levels are increased in early rheumatoid arthritis patients.

19. High expression of OX40 is associated with type 1 diabetes.

20. A cysteine-rich domain of CD134 that is critical for binding to the HHV-6B glycoprotein gH/gL/gQ1/gQ2 complex and HHV-6B infection.