BTLA Protein (AA 31-150) (His tag)
-
- Antigène Voir toutes BTLA Protéines
- BTLA (B and T Lymphocyte Associated (BTLA))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 31-150
-
Origine
- Humain
-
Source
- Human Cells
- Purification/Conjugué
- Cette BTLA protéine est marqué à la His tag.
- Fonction
- Recombinant Human B- and T-Lymphocyte Attenuator/BTLA/CD272 (C-6His)
- Séquence
- KESCDVQLYI KRQSEHSILA GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTGKQNEL SDTAGREINL VDHHHHHH
- Attributs du produit
- Recombinant Human B- and T-Lymphocyte Attenuator/BTLA is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Lys31-Leu150) of Human BTLA fused with a polyhistidine tag at the C-terminus.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product BTLA Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
-
It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Conseil sur la manipulation
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Stock
- 4 °C/-20 °C/-80 °C
- Stockage commentaire
-
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Date de péremption
- 3 months
-
- Antigène
- BTLA (B and T Lymphocyte Associated (BTLA))
- Autre désignation
- btla (BTLA Produits)
- Synonymes
- BTLA Protein, BTLA1 Protein, CD272 Protein, A630002H24 Protein, B and T lymphocyte associated Protein, BTLA Protein, Btla Protein
- Sub Type
- Fusionprotein
- Sujet
-
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
Alternative Names: B- and T-Lymphocyte Attenuator, B- and T-Lymphocyte-Associated Protein, CD272, BTLA - Poids moléculaire
- 14.79 kDa
- UniProt
- Q7Z6A9
- Pathways
- Cancer Immune Checkpoints
-