BCMA Protein (AA 2-54, Extracellular Domain) (Fc Tag)

N° du produit ABIN1344234

Détail du produit

Antigène: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Extracellular Domain, AA 2-54

Origine: Humain, Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette BCMA protéine est marqué à la Fc Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds human and mouse BAFF and APRIL.

Réactivité croisée: Humain, Souris

Attributs du produit: The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 50 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Référence

Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." dans: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).

Huard, Arlettaz, Ambrose, Kindler, Mauri, Roosnek, Tschopp, Schneider, French: "BAFF production by antigen-presenting cells provides T cell co-stimulation." dans: International immunology, Vol. 16, Issue 3, pp. 467-75, (2004) (PubMed).

Huard, Schneider, Mauri, Tschopp, French: "T cell costimulation by the TNF ligand BAFF." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6225-31, (2001) (PubMed).

Rennert, Schneider, Cachero, Thompson, Trabach, Hertig, Holler, Qian, Mullen, Strauch, Browning, Ambrose, Tschopp: "A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth." dans: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1677-84, (2000) (PubMed).

Détail du antigène

Antigène: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Autre désignation: BCMA (TNFRSF17 Produits)

Synonymes: TNFRSF17 Protein, BCM Protein, BCMA Protein, CD269 Protein, TNFRSF13A Protein, Tnfrsf13 Protein, Tnfrsf13a Protein, TNF receptor superfamily member 17 Protein, tumor necrosis factor receptor superfamily, member 17 Protein, Tnfrsf17 Protein, TNFRSF17 Protein

Sujet: BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappaB and JNK.

Poids moléculaire: ~40kDa (SDS-PAGE)

UniProt: Q02223