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Epigen Protein (AA 24-95)

EPGN Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
N° du produit ABIN2017765
  • Antigène Voir toutes Epigen (EPGN) Protéines
    Epigen (EPGN) (Epithelial Mitogen (EPGN))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 24-95
    Origine
    • 11
    • 1
    Humain
    Source
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Attributs du produit
    ED50 < 1 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 1x 10^3 units/mg.
    AA 24-95, expressed with an N-terminal Met.
    Pureté
    > 95 % by SDS-PAGE analysis.
    niveau d'endotoxine
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product EPGN Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Stock
    -80 °C
    Stockage commentaire
    Lyophilized recombinant human Epigen (rhEpigen) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhEpigen remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Date de péremption
    6 months
  • Antigène
    Epigen (EPGN) (Epithelial Mitogen (EPGN))
    Autre désignation
    Epigen (EPGN Produits)
    Synonymes
    ALGV3072 Protein, EPG Protein, PRO9904 Protein, 2310069M11Rik Protein, epigen Protein, RGD1560084 Protein, epithelial mitogen Protein, EPGN Protein, Epgn Protein
    Sujet
    Epigen is a cytokine belonging to the Epidermal Growth Factor (EGF) superfamily, which also includes Epiregulin, Amphiregulin, Neuregulin 2-beta, and Transforming Growth Factor alpha. The precursor of Epigen produced in tissues has 154 amino acids, and shares the characteristics of other members of EGF superfamily, including 3 disulfide bonds formed by 6 cysteines. Epigen is present in testis, heart, and liver, and it binds to EGF receptors with a much lower binding affinity than EGF. However, Epigen is more mitogenic than EGF. Epigen achieves its strong mitogenic potency by suppressing ligand-induced receptor inactivation. Unlike EGF, Epigen can also bind to EGF receptors in low pH conditions, helping its recycling. Therefore Epigen has anomalous potency due to its prolonged presence.Recombinant human Epigen (rhEpigen) produced in E. coli is a single non-glycosylated polypeptide chain containing 73 amino acids. A fully biologically active molecule, rhEpigen has a molecular mass of 8.1 kDa analyzed by reducing SDS-PAGE.
    Synonyms: EPG, Epithelial mitogen
    Poids moléculaire
    8.1 kDa, observed by reducing SDS-PAGE.
    Pathways
    Signalisation RTK, EGFR Signaling Pathway
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