Growth Hormone Receptor Protein (GHR) (AA 27-264) (His tag)
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- Antigène Voir toutes Growth Hormone Receptor (GHR) Protéines
- Growth Hormone Receptor (GHR)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 27-264
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Growth Hormone Receptor protéine est marqué à la His tag.
- Séquence
- AA 27-264
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >90 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GHR Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Nanofluidic device for continuous multiparameter quality assurance of biologics." dans: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
: "Mechanism of immobilized protein A binding to immunoglobulin G on nanosensor array surfaces." dans: Analytical chemistry, Vol. 87, Issue 16, pp. 8186-93, (2015) (PubMed).
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Nanofluidic device for continuous multiparameter quality assurance of biologics." dans: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
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- Antigène
- Growth Hormone Receptor (GHR)
- Autre désignation
- Growth Hormone R (GHR Produits)
- Synonymes
- GHBP Protein, AA986417 Protein, GHR/BP Protein, GHR Protein, ghr Protein, ghr.a Protein, zgc:162141 Protein, growth hormone receptor Protein, growth hormone receptor L homeolog Protein, growth hormone receptor a Protein, GHR Protein, Ghr Protein, ghr.L Protein, ghr Protein, ghra Protein
- Sujet
- Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
- Poids moléculaire
- 29.6 kDa
- NCBI Accession
- NP_000154
- UniProt
- P10912
- Pathways
- Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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