CD25 Protein (AA 22-213) (Fc Tag)
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- Antigène Voir toutes CD25 (IL2RA) Protéines
- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 22-213
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD25 protéine est marqué à la Fc Tag.
- Séquence
- AA 22-213
- Attributs du produit
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 Kda. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL2RA Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Antigène
- CD25 (IL2RA) (Interleukin 2 Receptor, alpha (IL2RA))
- Autre désignation
- IL-2 R alpha (IL2RA Produits)
- Synonymes
- CD25 Protein, IDDM10 Protein, IL2R Protein, TCGFR Protein, IL2RAC Protein, IL-2RA Protein, Il2r Protein, Ly-43 Protein, interleukin 2 receptor subunit alpha Protein, interleukin-2 receptor subunit alpha-like Protein, interleukin 2 receptor, alpha chain Protein, IL2RA Protein, Il2ra Protein, LOC100222957 Protein
- Sujet
- Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
- Poids moléculaire
- 48.4 kDa
- NCBI Accession
- NP_000408
- Pathways
- Signalistation JAK/STAT, Growth Factor Binding, Activated T Cell Proliferation
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