TRKB (NTRK2)
(Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
Type de proteíne
Recombinant
Attributs du protein
AA 32-430
Origine
Humain
Source
HEK-293 Cells
Purification/Conjugué
Cette TRKB protéine est marqué à la Fc Tag.
Séquence
AA 32-430
Attributs du produit
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.4 kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NTRK2
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Active
Restrictions
For Research Use only
Format
Lyophilized
Buffer
50 mM Tris, 100 mM Glycine, pH 7.5
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Antigène
TRKB (NTRK2)
(Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is ""ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate"". NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.