PCSK9 Protein (AA 31-691) (His tag)
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- Antigène Voir toutes PCSK9 Protéines
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 31-691
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PCSK9 protéine est marqué à la His tag.
- Séquence
- AA 31-691
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 22 and 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by reduced SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PCSK9 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Antigène
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Autre désignation
- PCSK9 (PCSK9 Produits)
- Synonymes
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- Sujet
- Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
- Poids moléculaire
- 13.9 kDa and 59.3 kDa
- NCBI Accession
- NP_954862
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