PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 31-691
Origine
Rat
Source
HEK-293 Cells
Purification/Conjugué
Cette PCSK9 protéine est marqué à la His tag.
Séquence
AA 31-691
Attributs du produit
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 22 and 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
PCSK9
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
PCSK9
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE
Active
Restrictions
For Research Use only
Format
Lyophilized
Buffer
50 mM Tris, 150 mM NaCl, pH 7.5
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Antigène
PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
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Sujet
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).