PDGFB Protein (Transcript Variant 1) (His tag)

N° du produit ABIN2728538

Détail du produit

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PDGFB protéine est marqué à la His tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PDGFB (transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Pureté: > 95 % as determined by SDS-PAGE and Coomassie blue staining

niveau d'endotoxine: < 0.1 EU per μg protein as determined by LAL test

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Buffer: Lyophilized from a 0.2 μM filtered solution of 4 mM HCl. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Autre désignation: Pdgfb (PDGFB Produits)

Synonymes: PDGF-2 Protein, PDGF2 Protein, SIS Protein, SSV Protein, c-sis Protein, pdgf2 Protein, sis Protein, si:ch211-79m20.1 Protein, si:dkey-261d11.1 Protein, PDGF-B Protein, Sis Protein, platelet derived growth factor subunit B Protein, platelet-derived growth factor beta polypeptide Protein, platelet derived growth factor subunit B S homeolog Protein, platelet-derived growth factor beta polypeptide a Protein, platelet derived growth factor, B polypeptide Protein, PDGFB Protein, pdgfb.S Protein, pdgfba Protein, Pdgfb Protein

Sujet: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 12.4 kDa

NCBI Accession: NP_002599

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling