PKC zeta Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2729631

Détail du produit

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PKC zeta protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PRKCZ (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Autre désignation: Prkcz (PRKCZ Produits)

Synonymes: TPKC Protein, PKCzeta Protein, prkcz-A Protein, pkc-zeta Protein, PRKCZ Protein, pkc2 Protein, PKC-ZETA Protein, PKC2 Protein, AI098070 Protein, C80388 Protein, Pkcz Protein, R74924 Protein, aPKCzeta Protein, zetaPKC Protein, 14-3-3-zetaisoform Protein, r14-3-3 Protein, pkcz Protein, si:ch211-150o23.4 Protein, protein kinase C zeta L homeolog Protein, protein kinase C zeta Protein, protein kinase C, zeta Protein, prkcz.L Protein, PRKCZ Protein, prkcz Protein, Prkcz Protein

Sujet: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 67.5 kDa

NCBI Accession: NP_002735

Pathways: Signalisation NF-kappaB, Signalisation RTK, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling