ITGAV/ITGB5 Protein (AA 31-992) (His tag)
ITGAV/ITGB5
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Func
Active
2 images
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- Antigène Tous les produits ITGAV/ITGB5
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 31-992
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ITGAV/ITGB5 protéine est marqué à la His tag.
- Application
- Functional Studies (Func)
- Séquence
- AA 31-992
- Attributs du produit
- Human ITGAV & ITGB5 Heterodimer Protein, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 113 kDa (ITGAV) and 81.9 kDa (ITGB5). Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidic tail and subunit ITGB5 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB5) respectively due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His-Avi Tag,Biotin)
ITGAV/ITGB5 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB5 Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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- Antigène
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Autre désignation
- Integrin alpha V beta 5 (ITGAV/ITGB5 Produits)
- Sujet
- Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
- Poids moléculaire
- 112.9 kDa (ITGAV) & 81.9 kDa (ITGB5)
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