ITGAV/ITGB5 Protein (Biotin,His-Avi Tag)

N° du produit ABIN7316901

Détail du produit

Antigène: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ITGAV/ITGB5 protéine est marqué à la Biotin,His-Avi Tag.

Fonction: Biotinylated Mouse Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag™&Tag Free

Séquence: Phe 31 - Val 988 & Gly 24 - Asn 719

Attributs du produit: Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein, His,Avitag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 24 - Asn 719 (Accession # P43406-1 & O70309-1).

Pureté: 95,00 %

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB5). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB5 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa (ITGB5) and 125-145 kDa (ITGAV)under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Autre désignation: Integrin alpha V beta 5 (ITGAV/ITGB5 Produits)

Sujet: Synonyms:Integrin alpha V beta 5,ITGAV&ITGB5,Description:Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Poids moléculaire: 114.2 kDa | 81.8 kDa